Characterization methods in porous materials for the rational design of multi-step processing in the context of a paper microfluidic phenylalanine test.

ABSTRACT: A promising application of paper microfluidics is the translation of gold-standard multi-step laboratory tests to a disposable paper-based format for decentralized diagnostic or therapeutic testing. This often entails conversion of bench-top processing of macro-volume samples to the processing of micro-volume samples within a porous matrix, and requires detailed characterization of fluid and reagent interactions within the porous material(s) of the device. The current study focuses on rational device design through the characterization of fluid and reagent interactions in polysulfone and glass fiber substrates for multi-step sample processing. Specifically, we demonstrate how the characterization of fluidic compatibility between substrates, chemical compatibility between reagents and subst

SUBMITTER: Wentland L 

PROVIDER: S-EPMC8654261 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature