Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model.

ABSTRACT:

Background

Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost agent and previous studies suggest that its use may promote metabolic health. However, its effects on some comorbidities associated with obesity are unknown. Herein, we investigated the hypothesis that melatonin supplementation would attenuate adipose-hepatic metabolic dysfunction in high fat diet (HFD)-induced obesity in male Wistar rats.

Materials and methods

Twenty-four adult male Wistar rats (n = 6/group) were used: Control group received vehicle (normal saline), obese group received 40% high fat diet, melatonin-treated group received 4 mg/kg of melatonin, and obese plus melatonin group received 40% HFD and

SUBMITTER: Obayemi MJ 

PROVIDER: S-EPMC8654266 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature