Inflammation causes remodeling of mitochondrial cytochrome <i>c</i> oxidase mediated by the bifunctional gene <i>C15orf48</i>.

ABSTRACT: Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory diseases. Cytochrome c oxidase (CcO), which mediates the rate-limiting step in mitochondrial respiration, is remodeled during development and in response to changes of oxygen availability, but there has been little study of CcO remodeling during inflammation. Here, we describe an elegant molecular switch mediated by the bifunctional transcript C15orf48, which orchestrates the substitution of the CcO subunit NDUFA4 by its paralog C15ORF48 in primary macrophages. Expression of C15orf48 is a conserved response to inflammatory signals and occurs in many immune-related pathologies. In rheumatoid arthritis, C15orf48 mRNA is elevated in peripheral monocytes and proinf

SUBMITTER: Clayton SA 

PROVIDER: S-EPMC8654286 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature