Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence.

ABSTRACT: Medulloblastoma (MB) remains a leading cause of cancer-related mortality among children. The paucity of MB samples collected at relapse has hindered the functional understanding of molecular mechanisms driving therapy failure. New models capable of accurately recapitulating tumor progression in response to conventional therapeutic interventions are urgently needed. In this study, we developed a therapy-adapted PDX MB model that has a distinct advantage of generating human MB recurrence. The comparative gene expression analysis of MB cells collected throughout therapy led to identification of genes specifically up-regulated after therapy, including one previously undescribed in the setting of brain tumors, bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4

SUBMITTER: Bakhshinyan D 

PROVIDER: S-EPMC8654291 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature