High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain.
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ABSTRACT:
SUBMITTER: Estrada H
PROVIDER: S-EPMC8654306 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
High-resolution fluorescence-guided transcranial ultrasound mapping in the live mouse brain.
Estrada Hector H Robin Justine J Özbek Ali A Chen Zhenyue Z Marowsky Anne A Zhou Quanyu Q Beck Daniel D le Roy Beau B Arand Michael M Shoham Shy S Razansky Daniel D
Science advances 20211208 50
Understanding the physiological impact of transcranial ultrasound in rodent brains may offer an important preclinical model for human scale magnetic resonance–guided focused ultrasound methods. However, precision tools for high-resolution transcranial ultrasound targeting and real-time in vivo tracking of its effects at the mouse brain scale are currently lacking. We report a versatile bidirectional hybrid fluorescence-ultrasound (FLUS) system incorporating a 0.35-mm precision spherical-phased a ...[more]
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