Comparison of ¹⁸F-FDG, ¹⁸F-Fluoroacetate, and ¹⁸F-FEPPA for Imaging Liver Fibrosis in a Bile Duct-Ligated Rat Model.

ABSTRACT: Developing sensitive diagnostic methods for a longitudinal evaluation of the status of liver fibrosis is a priority. This study is aimed at assessing the significance of longitudinal positron emission tomography (PET) imaging with ¹⁸F-labeling tracers for assessing liver fibrosis in a rat model with bile duct ligation (BDL). Twenty-one 6-week-old Sprague-Dawley male rats were used in this study. Longitudinal PET images using [¹⁸F]N-2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([¹⁸F]FEPPA) (n = 3), [¹⁸F]fluoroacetate ([¹⁸F]FAc) (n = 3), and 18F-fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) (n = 3) were obtained at 0, 1, and 2 weeks after BDL. Biochemical assays, histological assays, immunohistochemi

SUBMITTER: Wu CY 

PROVIDER: S-EPMC8654319 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature