Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries.

ABSTRACT: Therapeutic antibodies must have "drug-like" properties. These include high affinity and specificity for the intended target, biological activity, and additional characteristics now known as "developability properties": long-term stability and resistance to aggregation when in solution, thermodynamic stability to prevent unfolding, high expression yields to facilitate manufacturing, low self-interaction, among others. Sequence-based liabilities may affect one or more of these characteristics. Improving the stability and developability of a lead antibody is typically achieved by modifying its sequence, a time-consuming process that often results in reduced affinity. Here we present a new antibody library format that yields high-affinity binders with drug-like developability properties direc

SUBMITTER: Azevedo Reis Teixeira A 

PROVIDER: S-EPMC8654478 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature