Controlled Organization of Inorganic Materials Using Biological Molecules for Activating Therapeutic Functionalities.

ABSTRACT: Precise control over the assembly of biocompatible three-dimensional (3D) nanostructures would allow for programmed interactions within the cellular environment. Nucleic acids can be used as programmable crosslinkers to direct the assembly of quantum dots (QDs) and tuned to demonstrate different interparticle binding strategies. Morphologies of self-assembled QDs are evaluated via gel electrophoresis, transmission electron microscopy, small-angle X-ray scattering, and dissipative particle dynamics simulations, with all results being in good agreement. The controlled assembly of 3D QD organizations is demonstrated in cells via the colocalized emission of multiple assembled QDs, and their immunorecognition is assessed via enzyme-linked immunosorbent assays. RNA interference inducers are also

SUBMITTER: Chandler M 

PROVIDER: S-EPMC8654604 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature