Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions.

ABSTRACT:

Objective

Infantile spasms may evolve into persistent epilepsies including Lennox-Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple-hit model) or focal cortical inflammation and determined the anti-epileptogenic effects of pulse-rapamycin, previously shown to stop spasms in multiple-hit rats.

Methods

Spasms were induced in 3-day-old male rats via right intracerebral doxorubicin/lipopolysaccharide (multiple-hit model) infusions. Controls and sham rats were used. Separate multiple-hit rats received pulse-rapamycin or vehicle intraperitoneally between postnatal days 4 and 6. In adult mice, video-EEG (electroencephalography) scoring for seizures and sleep and histology were done blinded to treatment.

Resul

SUBMITTER: Akman O 

PROVIDER: S-EPMC8654607 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature