Measurement of glomerular filtration rate using endogenous d-serine clearance in living kidney transplant donors and recipients.

ABSTRACT:

Background

Endogenous molecules that provide an unbiased and a precise evaluation of kidney function are still necessary. We explored the potential of clearance of d-serine, a rare enantiomer of serine and a biomarker of kidney function, as a measure of glomerular filtration rate (GFR).

Methods

This was a cross-sectional observational study of 200 living kidney transplant donors and recipients enrolled between July 2019 and December 2020 in a single Japanese center, for whom GFR was measured by clearance of inulin (C-in). Clearance of d-serine (C-dSer) was calculated based on blood and urine levels of d-serine, as measured by two-dimensional high-performance liquid chromatography. Analytical performance was assessed by calculating biases. Utilizing data from 129 participants

SUBMITTER: Kawamura M 

PROVIDER: S-EPMC8654629 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature