In silico analysis of highly conserved cytotoxic T-cell epitopes in the structural proteins of African swine fever virus.

ABSTRACT:

Background and aim

African swine fever (ASF) is a viral disease of pigs caused by ASF virus (ASFV). High mortality and the lack of available treatments have severely impacted the swine industry resulting in huge global economic losses. In response to the dire necessity for vaccines, this study aims to identify highly conserved cytotoxic T-cell epitopes in ASFV structural proteins pp220, pp62, p72, p30, and CD2v through immunoinformatics approach.

Materials and methods

The amino acid sequences of the structural proteins were retrieved from the National Center for Biotechnology Information protein database. The sequences were evaluated in CD-HIT Suite wherein resulting representative sequences were aligned in Clustal Omega. Highly conserved sequences were identified in the Pro

SUBMITTER: Herrera LRM 

PROVIDER: S-EPMC8654742 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature