Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy.

ABSTRACT: Umbilical cord blood (UCB) cells are an important source of mesenchymal stem cells (MSCs). It is known that the umbilical cord is rich in hematopoietic stem cells, which influenced research on ontogeny and transplantation (allogeneic transplantation). In recent years, stem cell research has emerged as an area of major interest due to its prospective applications in various aspects of both human and veterinary medicine. Moreover, it is known that the application of MSCs has several weaknesses. The use of these cells has limitations in terms of tumorigenesis effect, delivery, safety, and variability of therapeutic response, which led to the use of secretomes as an alternative to cell-free therapy. The main obstacle in its use is the availability of human UCB as an origin of MSCs and MSCs' se

SUBMITTER: Kusindarta DL 

PROVIDER: S-EPMC8654746 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature