Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome.

ABSTRACT:

Background

parent-of-origin effects (POE) play important roles in complex disease and thus understanding their regulation and associated molecular and phenotypic variation are warranted. Previous studies mainly focused on the detection of genomic regions or phenotypes regulated by POE. Understanding whether POE may be modified by environmental or genetic exposures is important for understanding of the source of POE-associated variation, but only a few case studies addressing modifiable POE exist.

Methods

in order to understand this high order of POE regulation, we screened 101 genetic and environmental factors such as 'predicted mRNA expression levels' of DNA methylation/imprinting machinery genes and environmental exposures. POE-mQTL-modifier interaction models were propose

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC8654798 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature