Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis.

ABSTRACT: Spike glycoprotein (Sgp) is liable for binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the host receptors. Since Sgp is the main target for vaccine and drug designing, elucidating its mutation pattern could help in this regard. This study is aimed at investigating the correspondence of specific residues to the Sgp_SARS-CoV-2 functionality by explorative interpretation of sequence alignments. Centrality analysis of the Sgp dissects the importance of these residues in the interaction network of the RBD-ACE2 (receptor-binding domain) complex and furin cleavage site. Correspondence of RBD to threonine500 and asparagine501 and furin cleavage site to glutamine675, glutamine677, threonine678, and alanine684 was observed; all residues are exactly located at

SUBMITTER: Rahbar MR 

PROVIDER: S-EPMC8654821 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature