Essential role of a Plasmodium berghei heat shock protein (PBANKA_0938300) in gametocyte development.

ABSTRACT: The continued existence of Plasmodium parasites in physiologically distinct environments during their transmission in mosquitoes and vertebrate hosts requires effector proteins encoded by parasite genes to provide adaptability. Parasites utilize their robust stress response system involving heat shock proteins for their survival. Molecular chaperones are involved in maintaining protein homeostasis within a cell during stress, protein biogenesis and the formation of protein complexes. Due to their critical role in parasite virulence, they are considered targets for therapeutic interventions. Our results identified a putative P. berghei heat shock protein (HSP) belonging to the HSP40 family (HspJ62), which is abundantly induced upon heat stress and expressed during all parasite stages. To de

SUBMITTER: Kashif M 

PROVIDER: S-EPMC8654831 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature