An altered microbiome in a Parkinson's disease model Drosophila melanogaster has a negative effect on development.

ABSTRACT: Parkinson's disease (PD) is the second most common neurodegenerative disease, besides Alzheimer's Disease, characterized by multiple symptoms, including the well-known motor dysfunctions. It is well-established that there are differences in the fecal microbiota composition between Parkinson's disease (PD) patients and control populations, but the mechanisms underlying these differences are not yet fully understood. To begin to close the gap between description and mechanism we studied the relationship between the microbiota and PD in a model organism, Drosophila melanogaster. First, fecal transfers were performed with a D. melanogaster model of PD that had a mutation in the parkin (park²⁵) gene. Results indicate that the PD model feces had a negative effect on both pupation and

SUBMITTER: Parker-Character J 

PROVIDER: S-EPMC8654912 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature