The Mutations and Clinical Variability in Maternally Inherited Diabetes and Deafness: An Analysis of 161 Patients.

ABSTRACT:

Aims

To investigate the clinical features and mitochondrial mutations for maternally inherited diabetes and deafness.

Methods

PubMed, Embase, Medline, Web of Science, the China National Knowledge Infrastructure, and Wanfang were searched with the following search terms: "Maternally inherited diabetes and deafness" OR "MIDD" OR "Mitochondrial diabetes". The mutations and clinical features were analyzed. Correlation between the heteroplasmy levels of the m.3243A>G mutation in the peripheral blood and age at the onset of diabetes was conducted by Spearman test. The significance level was set as p < 0.05. Statistical analysis was performed using the Statistical Package for the Social Sciences version 26 for Windows.

Results

Totally 161 patients with 21 different mitochond

SUBMITTER: Yang M 

PROVIDER: S-EPMC8654930 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature