Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins.

ABSTRACT: Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected experimentally, prediction of protein structure. We have undertaken a major effort to use existing protein structures to collect, characterize, and catalogue the inter-atomic interactions that define and compose 3D structure by mapping hydropathic interaction environments as maps in 3D space. This work has been performed on a residue-by-residue basis, where we have seen evidence for relationships between environment character, residue solvent-accessible surface areas and their secondary structures. In this graphical review, we apply principles from our ear

SUBMITTER: Al Mughram MH 

PROVIDER: S-EPMC8654985 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature