Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels.

ABSTRACT:

Background

Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.

Objective

To determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of 2 common indoor allergens in children with asthma and low vitamin D levels.

Methods

Total IgE, IgE to Dermatophagoides pteronyssinus, and IgE to Blattella germanica were measured at the randomization and exit visits for 174 participants in the Vitamin D Kids Asthma Study, a multicenter, double-blind, randomized placebo-controlled trial of vitamin D₃ supplementation (4000 IU/d) to prevent severe exacerbations in children with persistent asthma and vitamin D levels less than 30 ng/mL. Multivariable linear regr

SUBMITTER: Rosser FJ 

PROVIDER: S-EPMC8655021 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature