Biomarkers for Deep Brain Stimulation in Animal Models of Depression.

ABSTRACT:

Objectives

Despite recent advances in depression treatment, many patients still do not respond to serial conventional therapies and are considered "treatment resistant." Deep brain stimulation (DBS) has therapeutic potential in this context. This comprehensive review of recent studies of DBS for depression in animal models identifies potential biomarkers for improving therapeutic efficacy and predictability of conventional DBS to aid future development of closed-loop control of DBS systems.

Materials and methods

A systematic search was performed in Pubmed, EMBASE, and Cochrane Review using relevant keywords. Overall, 56 animal studies satisfied the inclusion criteria.

Results

Outcomes were divided into biochemical/physiological, electrophysiological, and behavioral ca

SUBMITTER: Yuen J 

PROVIDER: S-EPMC8655028 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature