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Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.

ABSTRACT: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.

SUBMITTER: Ahouidi AD

PROVIDER: S-EPMC8655062 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.

Ahouidi Ambroise D AD Rodgers Mary A MA Padane Abdou A Leye Nafissatou N Olivo Ana A Mbow Moustapha M Mboup Aminata A Diaw Papa Alassane PA Dia Aminata A Harris Barbara B Padane Yacine Amet Dia YAD Lo Gora G Meyer Todd V TV Diedhiou Cyrille K CK Diagne Diabou D Kane Ndeye Coumba Toure NCT Cloherty Gavin G Mboup Souleymane S

Scientific reports 20211208 1

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N ...[more]

PMID: 34880295

Dataset Information

Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.

Publications

Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.

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