Inference of tissue relative proportions of the breast epithelial cell types luminal progenitor, basal, and luminal mature.

ABSTRACT: Single-cell analysis has revolutionised genomic science in recent years. However, due to cost and other practical considerations, single-cell analyses are impossible for studies based on medium or large patient cohorts. For example, a single-cell analysis usually costs thousands of euros for one tissue sample from one volunteer, meaning that typical studies using single-cell analyses are based on very few individuals. While single-cell genomic data can be used to examine the phenotype of individual cells, cell-type deconvolution methods are required to track the quantities of these cells in bulk-tissue genomic data. Hormone receptor negative breast cancers are highly aggressive, and are thought to originate from a subtype of epithelial cells called the luminal progenitor. In this paper, we

SUBMITTER: Bartlett TE 

PROVIDER: S-EPMC8655091 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature