Ontology highlight
ABSTRACT:
SUBMITTER: Bao L
PROVIDER: S-EPMC8655097 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Bao Lei L Li Jing J Solimani Farzan F Didona Dario D Patel Payal M PM Li Xiaoguang X Qian Hua H Ishii Norito N Hashimoto Takashi T Hertl Michael M Amber Kyle T KT
Frontiers in immunology 20211125
Laminin-332 pemphigoid is a rare and severe autoimmune blistering disease, caused by IgG autoantibodies targeting laminin-332 in the dermal-epidermal basement zone. Laminin-332 pemphigoid is characterized by variable inflammatory infiltrate and the predominance of non-complement-fixing antibodies. Given these findings, we hypothesized that IgG autoantibodies to laminin-332 directly resulted in keratinocyte expression of inflammatory factors. We performed RNA-seq on primary human keratinocytes tr ...[more]