A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation.

ABSTRACT:

Introduction

Eugenol is a major component of essential oils of several plants, it exhibits significant antiparasitic and acaricidal activities, yet its molecular targets remain unknown.

Objectives

We aimed to systematically investigate the mechanism of action and the potential targets of eugenol against P. cuniculi, and evaluate the safety for laying the theoretical foundation for clinical application as an acaricide.

Methods

Using RNA-Seq analysis, surface plasmon resonance analysis and RNA interference assay, the mode of action of eugenol against Psoroptes cuniculi was investigated. The effect on the mitochondrial membrane potential and complex I of PC12 cells and C6/36 cells was assayed to investigate the species specificity of eugenol in insects and

SUBMITTER: Shang XF 

PROVIDER: S-EPMC8655235 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature