Performance of the Prototype NovioSense Noninvasive Biosensor for Tear Glucose in Type 1 Diabetes.

ABSTRACT:

Introduction

We recently published the results of a pilot study measuring glucose in tear fluid. We now show the results of an additional 24 patients.

Methods

Twenty-four subjects were recruited from Haaglanden Diabetes Centre. The patients reported in a fasting state and were given a meal with half the usual dose of insulin during the test. The device was applied under the lower eyelid. Glucose levels from capillary blood and interstitial fluid with a flash glucose measurement device were recorded every 15 minutes; the current from the tear glucose sensor was recorded continuously. The eye surface and tolerability were regularly checked. A calibration algorithm to convert tear glucose to blood values was built using a neural network regression model and validated.

Result

SUBMITTER: Geelhoed-Duijvestijn P 

PROVIDER: S-EPMC8655288 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature