Intervention-related Deaths in the European Randomized Study of Screening for Prostate Cancer.

ABSTRACT:

Background

Identification of intervention-related deaths is important for an accurate assessment of the ratio of benefit to harm in screening trials.

Objective

To investigate intervention-related deaths by study arm in the European Randomized Study of Prostate Cancer Screening (ERSPC).

Design setting and participants

ERSPC is a multicenter trial initiated in the 1990s to investigate whether screening on the basis of prostate-specific antigen (PSA) can decrease prostate cancer mortality. The present study included men in the core age group (55-69 yr: screening group n = 112 553, control group n = 128 681) with 16-yr follow-up.

Outcome measurements and statistical analysis

Causes of death among men with prostate cancer in ERSPC were predominantly ev

SUBMITTER: Godtman RA 

PROVIDER: S-EPMC8655382 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature