Prostate Cancer-specific Survival After Radical Prostatectomy Is Improved Among Metformin Users but Not Among Other Antidiabetic Drug Users.

ABSTRACT:

Background

Metformin has been linked to improved survival among diabetic prostate cancer (PCa) patients, while hyperinsulinemia and insulin usage has been related to worse prognosis.

Objective

To evaluate the association of metformin and other antidiabetic drugs with PCa death and androgen deprivation therapy (ADT).

Design setting and participants

The study cohort included 14 424 men who underwent radical prostatectomy in Finland during 1995-2013. Cases were identified, and clinical data were collected from patient files and national registries using personal identification numbers.

Intervention

Information on the use of each antidiabetic drug during 1995-2014 was collected from prescription registry of the Social Insurance Institution of Finland.

Outcome me

SUBMITTER: Joentausta RM 

PROVIDER: S-EPMC8655383 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature