Statin prescription in patients with chronic obstructive pulmonary disease and risk of exacerbations: a retrospective cohort study in the Clinical Practice Research Datalink.

ABSTRACT:

Objective

Observational studies have suggested a beneficial effect of taking statins on frequency of chronic obstructive pulmonary disease (COPD) exacerbations. However, clinical trials of statins in people with COPD did not confirm those results. This study aimed to investigate this association using a methodological approach, which reduces the biases associated with some previous observational study designs.

Design

Retrospective cohort study comparing new-users of statins with non-users.

Setting

General practices in England contributing to the Clinical Practice Research Datalink in 2007-2017, with linkage to data on Hospital Episode Statistics inpatient episodes.

Participants

48 124 people with COPD, aged over 40 years, who had not been prescribed statin in t

SUBMITTER: Smith MC 

PROVIDER: S-EPMC8655534 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature