Use of interrupted time-series analysis to characterise antibiotic prescription fills across pregnancy: a Norwegian nationwide cohort study.

ABSTRACT:

Objectives

Antibiotics are the most frequently prescribed medications for pregnant and breastfeeding women. We applied interrupted time-series analysis (ITSA) to describe antibiotic prescription fills patterns in pregnant women and examined recurrent antibiotic fills in subsequent pregnancies.

Designs

A population-based drug utilisation study.

Setting

Norwegian primary care.

Participants

653 058 pregnancies derived from Medical Birth Registry of Norway linked to the Norwegian Prescription Database (2006-2016).

Main outcome measure

Proportion of pregnancies exposed to antibiotics aggregated by week in pregnancy time windows.

Statistical analyses

We descriptively analysed antibiotic prescription fills patterns and components in pregnant women. The c

SUBMITTER: Trinh NTH 

PROVIDER: S-EPMC8655575 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature