Many but small HIV-1 non-B transmission chains in the Netherlands.

ABSTRACT:

Objective

The aim of this study was to investigate introductions and spread of different HIV-1 subtypes in the Netherlands.

Design

We identified distinct HIV-1 transmission chains in the Netherlands within the global epidemic context through viral phylogenetic analysis of partial HIV-1 polymerase sequences from individuals enrolled in the ATHENA national HIV cohort of all persons in care since 1996, and publicly available international background sequences.

Methods

Viral lineages circulating in the Netherlands were identified through maximum parsimony phylogeographic analysis. The proportion of HIV-1 infections acquired in-country among heterosexuals and MSM was estimated from phylogenetically observed, national transmission chains using a branching process model that

SUBMITTER: Bezemer D 

PROVIDER: S-EPMC8655833 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature