Genetic Correlation and Bidirectional Causal Association Between Type 2 Diabetes and Pulmonary Function.

ABSTRACT:

Background

Observational studies have shown possible bidirectional association between type 2 diabetes (T2D) and pulmonary function, but the causality is not well defined. The purpose of this study is to investigate genetic correlation and causal relationship of T2D and glycemic traits with pulmonary function.

Methods

By leveraging summary statistics from large-scale genome-wide association studies, linkage disequilibrium score regression was first implemented to quantify genetic correlations between T2D, glycemic traits, and several spirometry indices. Then both univariable and multivariable Mendelian randomization analyses along with multiple pleiotropy-robust methods were performed in two directions to assess the causal nature of these relationships.

Results

Forced

SUBMITTER: Zhu J 

PROVIDER: S-EPMC8655865 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature