Characteristics of the vaginal microbiome in women with premature ovarian insufficiency.

ABSTRACT:

Purpose

To investigate the relationship between vaginal microbial community structure and premature ovarian insufficiency (POI).

Methods

Twenty-eight women with POI and 12 healthy women were recruited at Shenzhen Maternity and Child Healthcare Hospital between August and September 2020. Blood samples were collected for glucose tests and detection of sex hormone levels and vaginal secretions were collected for microbial group determination. Vaginal microbial community profiles were analysed by 16S rRNA gene sequencing using the Illumina MiSeq system (Illumina Inc., San Diego, CA, USA).

Results

Compared to the controls, the serum levels of follicle-stimulating hormone, luteinizing hormone, testosterone, and the follicle-stimulating hormone/luteinizing hormone ratio, sig

SUBMITTER: Wu J 

PROVIDER: S-EPMC8655991 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature