Signature changes in gut microbiome are associated with increased susceptibility to HIV-1 infection in MSM.

ABSTRACT:

Background

Men who have sex with men (MSM) have been disproportionately affected by HIV-1 since the beginning of the AIDS pandemic, particularly in the USA and Europe. Compared to men who have sex with women (MSW), MSM have a distinct fecal microbiome regardless of HIV-1 infection. However, it is unclear whether the MSM-associated gut microbiome affects the susceptibility and progression of HIV-1 infection. We studied fecal microbiome profiles, short-chain fatty acids, and blood plasma inflammatory cytokines of 109 HIV-1 seroconverters (SC) from the early, 1984-1985 phase of the HIV-1 pandemic in the Multicenter AIDS Cohort Study (MACS) before and after HIV-1 infection compared to 156 HIV-1-negative MACS MSM (negative controls [NC]).

Results

We found that family Succinivibri

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8656045 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature