Measurement of the Drug Sensitivity of Single Prostate Cancer Cells.
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ABSTRACT:
SUBMITTER: Abali F
PROVIDER: S-EPMC8656582 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Measurement of the Drug Sensitivity of Single Prostate Cancer Cells.
Abali Fikri F Baghi Narges N Mout Lisanne L Broekmaat Joska J JJ Tibbe Arjan G J AGJ Terstappen Leon W M M LWMM
Cancers 20211202 23
The treatment of cancer faces a serious challenge as cancer cells within patients are heterogeneous and frequently resistant to therapeutic drugs. Here, we introduce a technology enabling the assessment of single cancer cells exposed to different drugs. PCa cells were individually sorted in self-seeding microwells, cultured for 24 h, and then exposed to several drugs to induce (R1881) or inhibit (Enzalutamide/Abiraterone) the secretion of a protein (PSA). Cell viability and PSA secretion of each ...[more]
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