MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer.

ABSTRACT:

Background

poor prognosis primary breast cancers are typically treated with cytotoxic chemotherapy. However, recurrences remain relatively common even after this aggressive therapy. Comparison of matched tumours pre- and post-chemotherapy can allow identification of molecular characteristics of therapy resistance and thereby potentially aid discovery of novel predictive markers or targets for chemosensitisation. Through this comparison, we aimed to identify microRNAs associated with chemoresistance, define microRNA target genes, and assess targets as predictors of chemotherapy response.

Methods

cancer cells were laser microdissected from matched breast cancer tissues pre- and post-chemotherapy from estrogen receptor positive/HER2 negative breast cancers showing partial respo

SUBMITTER: Baxter DE 

PROVIDER: S-EPMC8656586 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature