Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey.

ABSTRACT: To develop and subsequently get cancer researchers to use organotypic three-dimensional (3D) models that can recapitulate the complexity of human in vivo tumors in an in vitro setting, it is important to establish what in vitro model(s) researchers are currently using and the reasons why. Thus, we developed a survey on this topic, obtained ethics approval, and circulated it throughout the world. The survey was completed by 101 researchers, across all career stages, in academia, clinical or industry settings. It included 40 questions, many with multiple options. Respondents reported on their field of cancer research; type of cancers studied; use of two-dimensional (2D)/monolayer, 2.5D and/or 3D cultures; if using co-cultures, the cell types(s) they co-culture; if using 3D cultures, whether

SUBMITTER: Martinez-Pacheco S 

PROVIDER: S-EPMC8656628 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature