Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling.

ABSTRACT:

Purpose

While the prevailing view holds that the prostaglandin E2 (PGE₂) signaling plays a vital role in endometriosis, PGE₂ also is known to be anti-fibrotic. We investigated the immunostaining of COX-2, EP2, and EP4, along with fibrotic content in ovarian endometrioma (OE) and deep endometriosis (DE) lesions, and in OE lesions from adolescent and adult patients. In addition, we evaluated the effect of substrate stiffness on the expression of COX-2, EP2, and EP4 in endometrial stromal cells.

Methods

Immunohistochemistry analysis of COX-2, EP2, and EP4, along with the quantification of lesional fibrosis, was conducted for OE and DE lesion samples and also OE lesion samples from adolescent and adult patients. The effect of substrate rigidity on fibroblas

SUBMITTER: Huang Q 

PROVIDER: S-EPMC8656679 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature