Performance Evaluation for Repair of HSGc-C5 Carcinoma Cell Using Geant4-DNA.

ABSTRACT: Track-structure Monte Carlo simulations are useful tools to evaluate initial DNA damage induced by irradiation. In the previous study, we have developed a Gean4-DNA-based application to estimate the cell surviving fraction of V79 cells after irradiation, bridging the gap between the initial DNA damage and the DNA rejoining kinetics by means of the two-lesion kinetics (TLK) model. However, since the DNA repair performance depends on cell line, the same model parameters cannot be used for different cell lines. Thus, we extended the Geant4-DNA application with a TLK model for the evaluation of DNA damage repair performance in HSGc-C5 carcinoma cells which are typically used for evaluating proton/carbon radiation treatment effects. For this evaluation, we also performed experimental measuremen

SUBMITTER: Sakata D 

PROVIDER: S-EPMC8656964 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature