Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety.
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ABSTRACT:
SUBMITTER: Delage JA
PROVIDER: S-EPMC8657097 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety.
Delage Judith Anna JA Gnesin Silvano S Prior John O JO Barbet Jacques J Le Saëc Patricia P Marionneau-Lambot Séverine S Gouard Sébastien S Chérel Michel M Bourgeois Mickael M Schaefer Niklaus N Viertl David D Fierle Julie Katrin JK Dunn Steven Mark SM Faivre-Chauvet Alain A
Cancers 20211125 23
1C1m-Fc, a promising anti-TEM-1 DOTA conjugate, was labeled with <sup>64</sup>Cu to target cancer cells for PET imaging and predicting the efficacy and safety of a previously studied [<sup>177</sup>Lu]Lu-1C1m-Fc companion therapy. DOTA-conjugated 1C1m-Fc was characterized by mass spectrometry, thin layer chromatography and immunoreactivity assessment. PET/CT and biodistribution studies were performed in human neuroblastoma xenografted mice. Absorbed doses were assessed from biodistribution resul ...[more]
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