Organ Specific Copy Number Variations in Visceral Metastases of Human Melanoma.

ABSTRACT: Malignant melanoma is one of the most aggressive skin cancers with high potential of visceral dissemination. Since the information about melanoma genomics is mainly based on primary tumors and lymphatic or skin metastases, an autopsy-based visceral metastasis biobank was established. We used copy number variation arrays (N = 38 samples) to reveal organ specific alterations. Results were partly completed by proteomic analysis. A significant increase of high-copy number gains was found in an organ-specific manner, whereas copy number losses were predominant in brain metastases, including the loss of numerous DNA damage response genes. Amplification of many immune genes was also observed, several of them are novel in melanoma, suggesting that their ectopic expression is possibly undere

SUBMITTER: Papp O 

PROVIDER: S-EPMC8657127 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature