Payload Delivery: Engineering Immune Cells to Disrupt the Tumour Microenvironment.

ABSTRACT: Although chimeric antigen receptor (CAR) T cells have shown impressive clinical success against haematological malignancies such as B cell lymphoma and acute lymphoblastic leukaemia, their efficacy against non-haematological solid malignancies has been largely disappointing. Solid tumours pose many additional challenges for CAR T cells that have severely blunted their potency, including homing to the sites of disease, survival and persistence within the adverse conditions of the tumour microenvironment, and above all, the highly immunosuppressive nature of the tumour milieu. Gene engineering approaches for generating immune cells capable of overcoming these hurdles remain an unmet therapeutic need and ongoing area of research. Recent advances have involved gene constructs for membrane-boun

SUBMITTER: Fowler D 

PROVIDER: S-EPMC8657158 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature