Neutrophil Extracellular Traps (NETs) in Cancer Metastasis.

ABSTRACT: Metastasis is the leading cause of cancer related morbidity and mortality. The metastatic process involves several identifiable biological stages, including tumor cell dissemination, intravasation, and the extravasation of circulating cancer cells to facilitate colonization at a distant site. Immune cell infiltration and inflammation within the tumor microenvironment coincide with tumor progression and metastatic spread and are thought to be the key mediators of this complex process. Amongst many infiltrating cells, neutrophils have recently emerged as an important player in fueling tumor progression, both in animal models and cancer patients. The production of Neutrophil Extracellular Traps (NETs) is particularly important in the pathogenesis of the metastatic cascade. NETs are composed o

SUBMITTER: Kaltenmeier C 

PROVIDER: S-EPMC8657162 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature