Radiotherapy in Medulloblastoma-Evolution of Treatment, Current Concepts and Future Perspectives.

ABSTRACT: Medulloblastoma is the most frequent malignant brain tumor in children. During the last decades, the therapeutic landscape has changed significantly with craniospinal irradiation as the backbone of treatment. Survival times have increased and treatments were stratified according to clinical and later molecular risk factors. In this review, current evidence regarding the efficacy and toxicity of radiotherapy in medulloblastoma is summarized and discussed mainly based on data of controlled trials. Current concepts and future perspectives based on current risk classification are outlined. With the introduction of CSI, medulloblastoma has become a curable disease. Due to combination with chemotherapy, survival rates have increased significantly, allowing for a reduction in radiation dose and a

SUBMITTER: Seidel C 

PROVIDER: S-EPMC8657317 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature