Identification of Immune-Related lncRNA Prognostic Signature and Molecular Subtypes for Glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is extensively genetically and transcriptionally heterogeneous, which poses challenges for classification and management. Long noncoding RNAs (lncRNAs) play a critical role in the development and progression of GBM, especially in tumor-associated immune processes. Therefore, it is necessary to develop an immune-related lncRNAs (irlncRNAs) signature.

Methods

Univariate and multivariate Cox regression analyses were utilized to construct a prognostic model. GBM-specific CeRNA and PPI network was constructed to predict lncRNAs targets and evaluate the interactions of immune mRNAs translated proteins. GO and KEGG pathway analyses were used to show the biological functions and pathways of CeRNA network-related immunity genes. Consensus Clus

SUBMITTER: Yu W 

PROVIDER: S-EPMC8657607 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature