Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling.

ABSTRACT: Attribution of specific roles to the two ubiquitously expressed PI 3-kinase (PI3K) isoforms p110α and p110β in biological functions they have been implicated, such as in insulin signalling, has been challenging. While p110α has been demonstrated to be the principal isoform activated downstream of the insulin receptor, several studies have provided evidence for a role of p110β. Here we have used isoform-selective inhibitors to estimate the relative contribution of each of these isoforms in insulin signalling in adipocytes, which are a cell type with essential roles in regulation of metabolism at the systemic level. Consistent with previous genetic and pharmacological studies, we found that p110α is the principal isoform activated downstream of the insulin receptor under physiological condit

SUBMITTER: Zhang B 

PROVIDER: S-EPMC8657683 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature