Histone 3 Lysine 27 Trimethylation Signature in Breast Cancer.

ABSTRACT: Cancer development and progression rely on complicated genetic and also epigenetic changes which regulate gene expression without altering the DNA sequence. Epigenetic mechanisms such as DNA methylation, histone modifications, and regulation by lncRNAs alter protein expression by either promoting gene transcription or repressing it. The presence of so-called chromatin modification marks at various gene promoters and gene bodies is associated with normal cell development but also with tumorigenesis and progression of different types of cancer, including the most frequently diagnosed breast cancer. This review is focused on the significance of one of the abundant post-translational modifications of histone 3- trimethylation of lysine 27 (H3K27me3), which was shown to participate in tumour su

SUBMITTER: Borkiewicz L 

PROVIDER: S-EPMC8657745 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature