Regulation of the Fructose Transporter Gene Slc2a5 Expression by Glucose in Cultured Microglial Cells.

ABSTRACT: Microglia play a role in the regulation of metabolism and pathogenesis of obesity. Microglial activity is altered in response to changes in diet and the body's metabolic state. Solute carrier family 2 member 5 (Slc2a5) that encodes glucose transporter 5 (GLUT5) is a fructose transporter primarily expressed in microglia within the central nervous system. However, little is known about the nutritional regulation of Slc2a5 expression in microglia and its role in the regulation of metabolism. The present study aimed to address the hypothesis that nutrients affect microglial activity by altering the expression of glucose transporter genes. Murine microglial cell line SIM-A9 cells and primary microglia from mouse brain were exposed to different concentrations of glucose and levels

SUBMITTER: Mizuno TM 

PROVIDER: S-EPMC8657830 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature