Unknown

Dataset Information

0

Changes in Exosomal miRNA Composition in Thyroid Cancer Cells after Prolonged Exposure to Real Microgravity in Space.

ABSTRACT: As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, researching the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Station, we are now taking advantage of the newest technological opportunities to gain more insight into the changes in cell-cell communication of these cells. Analyzing the exosomal microRNA composition after several days of microgravity might elucidate some of the proteomic changes we have reported earlier. An array scan of a total of 754 miRNA targets revealed more than 100 differentially expressed miRNAs in our samples, many of which have been implicated in thyroid disease in other studies.

SUBMITTER: Wise PM 

PROVIDER: S-EPMC8657878 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Changes in Exosomal miRNA Composition in Thyroid Cancer Cells after Prolonged Exposure to Real Microgravity in Space.

Wise Petra M PM   Neviani Paolo P   Riwaldt Stefan S   Corydon Thomas J TJ   Wehland Markus M   Braun Markus M   Krüger Marcus M   Infanger Manfred M   Grimm Daniela D  

International journal of molecular sciences 20211127 23

As much as space travel and exploration have been a goal since humankind looked up to the stars, the challenges coming with it are manifold and difficult to overcome. Therefore, researching the changes the human organism undergoes following exposure to weightlessness, on a cellular or a physiological level, is imperative to reach the goal of exploring space and new planets. Building on the results of our CellBox-1 experiment, where thyroid cancer cells were flown to the International Space Stati  ...[more]

Similar Datasets

Unknown Changes in Exosome Release in Thyroid Cancer Cells after Prolonged Exposure to Real Microgravity in Space.
| S-EPMC7924847 | biostudies-literature
Unknown Prolonged Exposure to Simulated Microgravity Changes Release of Small Extracellular Vesicle in Breast Cancer Cells.
| S-EPMC9781806 | biostudies-literature
Unknown Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity.
| S-EPMC9839680 | biostudies-literature
Unknown Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila.
| S-EPMC7787258 | biostudies-literature
Genomics Changes in exosomal miRNA from macrophage under silica exposure
2022-04-02 | GSE199770 | GEO
Unknown Modulation of Exosomal miRNA, Danger Signals, and Inflammatory Proteins after Acute Stressor Exposure
| S-BSST106 | biostudies-other
Genomics Changes in exosomal miRNA from macrophage under silica exposure
| PRJNA821471 | ENA
Genomics Synergistic effects of space radiation and microgravity (miRNA WT and dys-mutant)
2017-03-01 | GSE90823 | GEO
Transcriptomics Transcription profiling of Drosophila after exposure to microgravity in the International Space Station and in a microgravity simulator
2010-07-01 | E-MEXP-2064 | biostudies-arrayexpress
Unknown Exosomal Small RNA Sequencing Uncovers Dose-Specific MiRNA Markers for Ionizing Radiation Exposure.
| S-EPMC7263154 | biostudies-literature