Fetal Immunomodulatory Environment Following Cartilage Injury-The Key to CARTILAGE Regeneration?

ABSTRACT: Fetal cartilage fully regenerates following injury, while in adult mammals cartilage injury leads to osteoarthritis (OA). Thus, in this study, we compared the in vivo injury response of fetal and adult ovine articular cartilage histologically and proteomically to identify key factors of fetal regeneration. In addition, we compared the secretome of fetal ovine mesenchymal stem cells (MSCs) in vitro with injured fetal cartilage to identify potential MSC-derived therapeutic factors. Cartilage injury caused massive cellular changes in the synovial membrane, with macrophages dominating the fetal, and neutrophils the adult, synovial cellular infiltrate. Correspondingly, proteomics revealed differential regulation of pro- and anti-inflammatory mediators and growth-factors between adult and fetal

SUBMITTER: Ribitsch I 

PROVIDER: S-EPMC8657887 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature