The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.

ABSTRACT: DNA entanglements and supercoiling arise frequently during normal DNA metabolism. DNA topoisomerases are highly conserved enzymes that resolve the topological problems that these structures create. Topoisomerase II (TOPII) releases topological stress in DNA by removing DNA supercoils through breaking the two DNA strands, passing a DNA duplex through the break and religating the broken strands. TOPII performs key DNA metabolic roles essential for DNA replication, chromosome condensation, heterochromatin metabolism, telomere disentanglement, centromere decatenation, transmission of crossover (CO) interference, interlock resolution and chromosome segregation in several model organisms. In this study, we reveal the endogenous role of Arabidopsis thaliana TOPII in normal root growth and cell cy

SUBMITTER: Martinez-Garcia M 

PROVIDER: S-EPMC8658145 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature